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You obviously do realise that the four parameters you mentioned only do suggest SIRS (Systemic Inflammatory Response Syndrome).

Sepsis has been diagnosed according to the consensus guidelines established in 1991 as an infection in addition to the symptoms of systemic inflammatory response syndrome (SIRS).

Amendments to these criteria were initiated by convening an international conference in 2001 in response to a survey revealing that 71% of responding clinicians considered the existing definitions insufficient (Just like how you feel!!!). The 2001 conference added several new diagnostic criteria for sepsis in addition to the previous criteria. Of particular interest was the inclusion of the biomarkers procalcitonin (PCT) and C-reactive protein (CRP), despite the overall conclusion that it was premature to use biomarkers for sepsis diagnosis.

Implementation of the PIRO (Predisposition, Infection, Response, and Organ dysfunctions) taging system was one of the major recommendation of the panel to determine optimum treatment for individual patients by stratifying their individual symptoms and risks.

The focus of the PIRO system on individualized patient treatment acknowledges the concerns of authors who have previously identified the need for individualized diagnostics and treatment. However, the PIRO outline fails to address the necessity of prompt diagnosis.

Given that swift diagnosis is crucial in permitting timely treatment, the majority of current research has focused on the search for a magic bullet biomarker as a provision for confirmed pathogen presence. In an effort to improve diagnostic efficiency and ultimate survivability, it is suggested that real-time protein detection technologies be used to monitor a panel of sepsis-related biomarkers. As to how feasible this process is, only time will tell...