Thread subject: NEPI :: Endosulfan poisoning

Posted by maroju on 08-02-2008 18:05
#2

It must've been a nightmare scenario, what with such a multitude of problems.

Personally I have no experience in dealing with Endosulfan (organochlorine) poisoning. There is a reported case of severe impairment of cerebral function and continued seizures ia a patient one year after the suicidal ingestion of an endosulfan containing formulation. (Shemesh et al. 1988)

Looks like you threw most anticonvulsants at that rather adamant seizure... Apart from suggesting Diazepam/lorazepam IV as 1st line, the literature suggests Phenytoin IV (loading dose of 15mg/kg infusion) for the unresponsive ones.

It is not clear from your account if this patient was adequately paralysed...

Some references:

Blanco-Coronad JL et al. acute intoxication by endosulfan. Clin Toxicol 1992; 30: 575-583

Shemesh Y et al. Survival after acute endosulfan intoxication. Clin Toxicol 1988; 26: 265-268

Olanoff LS et al. Acute chlordane intoxication. J Toxicol-Clin Toxicol 1983; 20: 291

Pradhan S et al. Selective involvement of basal ganglia and occipital cortex in a patient with acute endosulfan poisoning. J Neurol Sci 1997; 147: 209-13